MEK Inhibitor U0126 from Promega

Product Specs
ItemMEK Inhibitor U0126
CompanyPromega
Price Supplier Page View Company Product Page
Catalog NumberV1121
Quantity5mg

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Promega

2800 Woods Hollow Rd.

Madison, Wisconsin

United States

Phone: 800-356-9526
Fax: 800-356-1970

Company Profile

Website: http://www.promega.com

(1) Protocadherin 15 suppresses oligodendrocyte progenitor cell proliferation and promotes motility through distinct signalling pathwaysCommunications BiologyDecember 1, 2022Yilan Zhen, Carlie L. Cullen, Raphael Ricci, Benjamin S. Summers, Sakina Rehman, Zubair M. Ahmed, Antoinette Y. Foster, Ben Emery, Robert Gasperini, Kaylene M. Youngcomplete culture medium. Delivery of pharmacological agents to OPCs The MEK inhibitor (U0126, Promega, V1121), Arp2/3 inhibitor (CK666, Millipore, 182515) and Cdc42 inhibitor (ML141, Sigma, SML0407) were reconstituted

(2) A Systems Biology Approach to Investigate Kinase Signal Transduction Networks That Are Involved in Triple Negative Breast Cancer Resistance to CisplatinJournal of Personalized MedicineAugust 3, 2022Nupur Mukherjee et al.AICAR (Acadesine) (NA03552) and QNZ (EVP4593) (1237744-13-6) were purchased from Carbosynth, and U0126 (V1121) was purchased from Promega. QNZ (EVP4593), Ipatasertib, Stattic, CHIR-98014, PF-4708671, AICAR (Acadesine),

(3) Anti‑oncogenic and pro‑myogenic action of the MKK6/p38/AKT axis induced by targeting MEK/ERK in embryonal rhabdomyosarcomaOncology ReportsJuly 8, 2022Agnese Di Rocco et al.MilliporeSigma) for 1 day, 10 µM U0126 MEK inhibitor for 3 h, overnight (O/N), 1 day or 3 days (cat. no. V1121; Promega Corporation) or 10 nM trametinib for 3 h, overnight (O/N) or 3 days (cat. no. SC-364639; Santa Cruz Biotechnology, Inc

(4) Transglutaminase 2 enhances hepatocyte growth factor signaling to drive the mesothelioma cancer cell phenotypeMolecular CarcinogenesisJune 1, 2022Warren Naselsky, Gautam Adhikary, Suruchi Shrestha, Xi Chen, Geraldine Ezeka, Wen Xu, Joseph S Friedberg, Richard L. EckertERK1/2-inhibitor LY3214996 (S8534) was obtained from Selleckchem (Houston, TX) and the MEK1/2-inhibitor U0126 (V1121) was purchased from Promega (Madison, WI). Anti-transglutaminase 2 (TG2) (MAB3839) and SGX-523 MET inhibitor

(5) Blocking STAT3 signaling augments MEK/ERK inhibitor efficacy in esophageal squamous cell carcinomaCell death & diseaseMay 25, 2022Zheng ZY, Chu MY, Lin W, Zheng YQ, Xu XE, Chen Y, Liao LD, Wu ZY, Wang SH, Li EM, et al.beneficial for ESCC therapy. Materials and methods Reagents and antibodies The MEK1/2 inhibitor U0126 (V1121) was purchased from Promega. Trametinib (MEK1/2 inhibitor, HY-10999), Stattic (STAT3 inhibitor, HY-13818),

(6) Rgs4 is a regulator of mTOR activity required for motoneuron axon outgrowth and neuronal development in zebrafishScientific ReportsDecember 1, 2021Aya Mikdache, Marie-José Boueid, Lorijn van der Spek, Emilie Lesport, Brigitte Delespierre, Julien Loisel-Duwattez, Cindy Degerny, Marcel Tawktreatment Embryos were incubated in either 10 μM of Ly294002 (Cell signaling, #9901), 20 μM of U0126 (Promega, #V1121) or a combination of both, 10 μM of Rapamycin (Sigma, #R0395) and 50 μM of MHY1485 (Sigma, #SML0810),

(7) Calcium Dobesilate Modulates PKCδ-NADPH Oxidase- MAPK-NF-κB Signaling Pathway to Reduce CD14, TLR4, and MMP9 Expression during Monocyte-to-Macrophage Differentiation: Potential Therapeutic Implications for AtherosclerosisAntioxidants (Basel, Switzerland)November 11, 2021Njau F, Haller H.protease inhibitors PMSF (phenylmethanesulfonyl fluoride; P7626) and leupeptin (L851). The MAPK inhibitor (U0126; V1121) was from Promega, (Walldorf, Germany), while the PKCδ inhibitor rottlerin (sc-3550) and the calpain

(8) A cell-based drug discovery assay identifies inhibition of cell stress responses as a new approach to treatment of epidermolysis bullosa simplexJournal of Cell ScienceOctober 1, 2021Tong San Tan, John E. A. Common, John S. Y. Lim, Cedric Badowski, Muhammad Jasrie Firdaus, Steven S. Leonardi, E. Birgitte Laneeither glass coverslips, dishes or plates prior to DMSO and drug treatments. The MEK inhibitor U0126 (#V1121, Promega Corporation, WI, USA) and the EGFR inhibitors AG1478 (#658552, Calbiochem, MA, USA), lapatinib

(9) Localization of KRAS downstream target ARL4C to invasive pseudopods accelerates pancreatic cancer cell invasioneLifeSeptember 30, 2021Harada A, Matsumoto S, Yasumizu Y, Shojima K, Akama T, Eguchi H, Kikuchi A.,Thermo Fisher Scientific,"23,227", "Chemical compound, drug",PD184161,Sigma-Aldrich,PZ0112, "Chemical compound, drug",U0126,Promega Corp.,V1121, "Chemical compound, drug",Rapamycin,Cell Signaling Technology,"9,904", "Chemical compound, drug",LY294002,Cell Signaling Technology

(10) Paladin is a phosphoinositide phosphatase regulating endosomal VEGFR2 signalling and angiogenesisEMBO reportsFebruary 3, 2021Nitzsche A, Pietilä R, Love DT, Testini C, Ninchoji T, Smith RO, Ekvärn E, Larsson J, Roche FP, Egaña I, et al.retrieval and lysis of hearts or lungs at specific time points and immunoblotting. MEK inhibitor U0126 (V1121, Promega) was injected intraperitoneally (5 mg/kg). For short treatment, pups were injected twice at

(11) Group III metabotropic glutamate receptors gate long-term potentiation and synaptic tagging/capture in rat hippocampal area CA2eLifeApril 20, 2020Ananya Dasgupta, Yu Jia Lim, Krishna Kumar, Nimmi Baby, Ka Lam Karen Pang, Amrita Benoy, Thomas Behnisch, Sreedharan Sajikumarof 50 µM was made in aCSF and co-applied for 1 hr with (RS)-CPPG/UBP1112. The MEK inhibitor U0126 (#V1121, Promega, Madison, Wisconsin) was stored as 20 mM stock in DMSO. The other MEK inhibitor PD98059 (#9900L,

(12) Fractionation of Ovarian Follicles and in vitro Oocyte Maturation and Ovulation Assay of Ciona intestinalis Type ABIO-PROTOCOLApril 5, 2020Shin Matsubara, Akira Shiraishi, Tomohiro Osugi, Tsuyoshi Kawada, Honoo Satake2008) 11. Negative factors of oocyte maturation and ovulation, e.g., U0126 (Promega, catalog number: V1121) Ro-3306 (Abcam, catalog number: ab141491) MMP-2/MMP-9 inhibitor II (Calbiochem, catalog number: 444249) 12.

(13) IPF pathogenesis is dependent upon TGFβ induction of IGF-1FASEB journal : official publication of the Federation of American Societies for Experimental BiologyApril 1, 2020Hernandez DM, Kang JH, Choudhury M, Andrianifahanana M, Yin X, Limper AH, Leof EB.USA)",20 μM,0.1% DMSO MK2206,AKT,S1078,"Selleck Chemicals(Houston, TX, USA)",300 nM,0.1% DMSO U0127,MEK,V1121,"Promega(Madison, WI, USA)",10 μM,0.1% DMSO Rapamycin,mTORC1/2,S1039,"Selleck Chemicals(Houston, TX,

(14) Endothelial EphB4 maintains vascular integrity and transport function in adult hearteLifeNovember 29, 2019Luxán G, Stewen J, Díaz N, Kato K, Maney SK, Aravamudhan A, Berkenfeld F, Nagelmann N, Drexler HC, Zeuschner D, et al.1130), PP2 (final concentration 25 µM, Tocris, 1407) and U0126 (final concentration 10 µM, Promega, V1121). DMSO was used as vehicle control. Immunoprecipitation To analyze pSrc level in HUVECs, Src protein

(15) The regulation of oocyte maturation and ovulation in the closest sister group of vertebrateseLifeOctober 1, 2019Shin Matsubara, Akira Shiraishi, Tomohiro Osugi, Tsuyoshi Kawada, Honoo Satakeprotein",CiVP,"Kawada et al., 2008 (PMID: 18586058)",,5 μM "Chemical compound, drug",U0126,Promega,Cat.#:V1121,10 μM "Chemical compound, drug",Ro-3306,Abcam,Cat.#:ab141491,1 μM "Chemical compound, drug",MMP-2/MMP-9

(16) Fibroblast Growth Factor 2 lethally sensitizes cancer cells to stress-targeted therapeutic inhibitorsMolecular oncologyFebruary 1, 2019Dias MH, Fonseca CS, Zeidler JD, Albuquerque LL, da Silva MS, Cararo-Lopes E, Reis MS, Noël V, Dos Santos EO, Prior IA, et al.Cambridge, MA, USA); colchicine (Sigma C9754, St. Louis, MO, USA); the MEK inhibitor U0126 (Promega V1121, Madison, WI, USA); bortezomib (#S1013); ATM inhibitor KU55933 (#S1092); ATR inhibitor VE‐821 (#S8007);

(17) Trapping, tagging and tracking: Tools for the study of proteins during early development of the sea urchinMethods in cell biologyJanuary 1, 2019Roux-Osovitz MM, Foltz KR, Oulhen N, Wessel G.Wessel, 2004" PD98059,MEK,2.5 μM,Promega #V1191,"Carroll et al, 2000" U0126,MEK,2 – 20 μM,Promega #V1121,"Houel-Renault et al, 2013; Kumano et al, 2001; Mulner-Lorillon et al, 2017; Kisielewska et al, 2009" FR180204,MAPK

(18) Annexin A1-suppressed autophagy promotes nasopharyngeal carcinoma cell invasion and metastasis by PI3K/AKT signaling activationCell Death & DiseaseDecember 1, 2018Jin-Feng Zhu et al.Chloroquine(C6628) were purchased from Sigma-Aldrich. MK2206 (#S1078) was purchased from SelleckChemicals. U0126 (V1121) was purchased from Promega. Plasmids expressing AKT or SQSTM1 and control plasmid pReceive-M13 were

(19) Innately activated TLR4 signal in the nucleus accumbens is sustained by CRF amplification loop and regulates impulsivityBrain, behavior, and immunityMarch 1, 2018Balan I, Warnock KT, Puche A, Gondre-Lewis MC, Aurelian L.of MAPK extracellular signaling regulated kinase (ERK) kinase (MEK), U0126 (20 µM; Promega, Cat. # V1121) were added to the cultures 24 h before cell collection. By inhibiting MEK1/2, U0126 prevents the activation

(20) Ras/ERK-signalling promotes tRNA synthesis and growth via the RNA polymerase III repressor Maf1 in DrosophilaPLoS geneticsFebruary 1, 2018Sriskanthadevan-Pirahas S, Deshpande R, Lee B, Grewal SS.100 U/ml streptomycin (Gibco; 15140). Cells were treated with either 10 μM U0126 (Promega Cat. No. V1121) or DMSO (Sigma; D2650) for 2 hours. Then cells were washed twice with ice-cold PBS. Cells were then

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